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Because these side-effects are often mild and temporary, they are sometimes dismissed

The standard clinical protocol involves gradual dose escalation designed to minimize gastrointestinal side effects while building toward therapeutic levels

Whether its tap water, or drinking filtered water is one way to ensure taste and safety, or warm water, absorption timelines are similar

M.et al (2008)

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Interestingly, the rhythm of total urine volume per hour was maintained in both groups, increasing during the active phase and decreasing during the inactive phase in both groups (Fig