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Study selection was guided by the following PICO-derived questions In individuals with fibromyalgia, does increased oxidative stress or mitochondrial dysfunction (compared to healthy controls) correlate with greater symptom severity and inflammatory biomarkers

doi: 10.1159/000356067

Because EGCg is a relatively small, lipophilic (fat-soluble) molecule, it possesses the unique ability to cross the blood-brain barrier
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(PubMed) Hoffmann PR, Berry MJ

Antioxidant potential of vitamins A.E and C in modulating oxidative stress in rat brain