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The authors first synthesize the key iodo-lenalidomide intermediate (95) and then replace the iodide by a palladium-catalyzed coupling reaction with a mild base using a boronic ester functional group, isolating the desired products (97) using flash column chromatography 129

There were no nuclear morphological changes, DNA fragmentation, and caspase activation, and this process could not be reversed by caspase inhibitors

PPARdelta activation protects endothelial function in diabetic mice

Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL

The observation of metal sulphides as neutral fragments in the unimolecular decomposition of bio-organic ions is relatively rare, and only one case has been very recently reported in a study of lead-binding metallothionein [122] (see below)

A uniform layer of mesoporous MnO 2 was grown on the surface of as-made silica nanoparticles by simply mixing them with manganese permanganate (KMnO 4 ), which was reduced by unreacted organosilica existing on those freshly prepared silica nanoparticles