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Structural basis for activation of fatty acid-binding protein 4

Focus is also placed on its capacity to modulate intracellular glutathione (GSH) levels and influence the Nrf2/Keap1 signalling pathway, which governs cellular antioxidant defences and redox homeostasis

doi: 10.1016/j.chemosphere.2011.12.028 54 ZhuY

Trends Endocrinol Metab (1992) 3:17583

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Briefly, both enzymatic and non-enzymatic crosslinks affect the collagen structure, altering both tissue biomechanics ( e.g ., altered tissue elastic modulus, ultimate tensile strength, stress relaxation, etc .) and failure mechanisms ( e.g ., crosslink breakage, load transfer, etc .)