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Their real advantage over fad diets and over-the-counter fat burners is honest: predictable nutrient dosing, documented physiologic roles, and administration under medical supervision

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As bacterial-derived LPS has a key role in the increase in gut permeability, changes in the gut microbiota must be a contributory factor to the pathogenesis of obesity and diabetes 109

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Reference standards typically appear as a fine lyophilized powder with a characteristic blue tint when adequate copper is bound visual confirmation, though not a substitute for HPLC and mass spectrometry