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Examples include testosterone , estrogen , cortisol , and anabolic-androgenic steroids

Rare variants may not only cause typical familial disease but may also contribute to the burden of apparent sporadic cSVD- for example in the UK Biobank study by Cho and colleagues such rare NOTCH3 variants accounted for 0.21% of all strokes and 0.77% of all vascular dementias in the general population (362)

Passive diffusion accounts for 1.2% of overall absorption, with little effect on bioavailability in patients with pernicious anemia or gastro-duodenal resection [49, 50]

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Nausea incidence is similar, affecting 25-35% of users on both drugs

10.1179/1476830511Y.0000000028 [DOI] [PubMed] [Google Scholar] Albassam A