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These include oxidized LDL (ox-LDL), cholesterol crystals and calcium phosphate crystals in the former case, as well as HSPs, HMGB1, ATP, nuclear and mtDNA, and RNA in the latter one [134]

doi: 10.1016/j.saa.2019.117216

PMID 16591538

[Para 74] It appears that TNF-a decreases the availability of reduced glutathione, resulting in an increase in local oxidation stress, and at the same time sensitizes the membrane of the cell to increased damage from oxidation stress

The highest relative risk estimate was observed in long-term ( 30 prescriptions) users of metformin (adjusted OR, 1.83

98 Current and emerging treatment paradigms for cNF There is currently no effective therapy for cNFs, and the mainstay of clinical management involves monitoring and informing the patients about their prognosis and the nature of their tumours