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Acyl-CoA is catabolized in the -oxidation pathway to generate acetyl-CoA, which enters the citric acid cycle

It has a strong affinity for copper ions, which are essential cofactors in enzyme processes related to tissue maintenance and repair

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ROS also can promote the oligomerization and autophosphorylation of ASK1 through the oxidation of thioredoxin that, in its oxidized form, disassociates from ASK1, permitting oligomerization and activation of the latter (84)