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Proline is essential for collagen synthesis, while polyamines mediate diverse functions such as gene expression, translation, cell proliferation, cell growth, cell signaling, membrane stability, and cell death (Kusano et al., 2008

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As expected, the inhibition of GPx2 expression by siRNA led to significant growth inhibition in both rat and human breast cancer cell lines [19, 98]

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further confirmed that hypoxia participates in the pathogenesis of MS by modulating EndoMT-related genes, potentially involving transforming growth factor- (TGF-), NF-B, TNF, and mTOR signaling pathways (171)

Herein, Holstein cows were supplemented with 25 g/d rumen-protected carnitine from 42 d prepartum until 126 d postpartum ( n = 16) or assigned to the control group with no supplementation during the same period ( n = 14)