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In the context of senescence, PD-1 and PD-L1 are overexpressed in several in vitro models induced by drugs or related to normal aging phenotype 45

Other microbial metabolites, such as polysaccharide A and retinoic acid produced by commensal Clostridia , Faecalibacterium prausnitzii , and Bacteroides fragilis , induce the accumulation of regulatory T (Treg) cells, which suppress inflammation (Forbes et al., 2016)

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