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Imagine a bicycle chain: when one link is fixed or stabilized due to wear, the surrounding links endure greater pressure, increasing their risk of damage and potentially requiring further repair

IS03 displayed the highest inhibitory effect against Salm

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These molecular changes contribute to cell protection through multiple synergistic mechanisms: (1) Reduced Ang II levels lead to reduced NADPH oxidase activity and reduced ROS generation, thereby alleviating oxidative stress

Activation, mtDNA, particularly in its oxidized form (ox-mtDNA), can also directly activate the NLRP3 inflammasome, promoting caspase-1 activation, maturation of IL-1 and IL-18, and GSDMD (Gasdermin D)-mediated pyroptosis, thereby fueling chronic inflammation (29, 77, 78)

Extracts promote activity of FXR to ameliorate alcoholic liver disease: targeting liver lipid deposition and inflammation