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Even the small folate cycle can only proceed to a limited extent because the supply of THF from the large folate cycle is no longer given

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the 2.4 mg dose produced 16.9%, only 3.7% more despite more than doubling the dose and significantly increasing GI side effects (Wilding et al., NEJM 2021)

The results of this study will be presented at the 80th Annual Meeting of the Japan Society of Nutrition and Food Science*3, to be held from May 15 to May 17, 2026, and have been accepted for publication in the international scientific journal Nutrition Research.*4 *1 An amino acid found in abundance in plants of the Cucurbitaceae family, has been reported to support blood flow and help maintain vascular flexibility
