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PLoS One 9:e111899

Although all four FXR isoforms encode identical ligand binding domains, the abundance of the isoforms vary between tissues and there are differences in their relative transcriptional activity
References PubMed

J., Riffelmacher, T., Braas, D., Cornall, R

doi: 10.1074/jbc.M607007200

That is where lipotropic injections provide their greatest value, as a bridge between intention and action