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In addition to their role as immune-associated cytokines, both TNF- and IL-6 have been shown to alter ion channel expression, interact directly with neuron ion channels, and modulate neural activity in the absence of immune cells (Vezzani and Viviani, 2015
Through the thiol groups of the cysteine residues, they form tight complexes with metal ions such as Cd++ , Ag+ , Pb++ , Cu++ , Hg++ , and Zn++ as well as with the semimetal As3 (Fig
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