most common place for melanotic macule a at the wet–dry line of the lower lip. b Melanotic Oral Mucosal Melanosis | IntechOpen

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PPAR is also involved in carnitine transport and uptake processes, and treatment with its activator increases the transcript levels of OCTN2 and OCTN3 [195, 196]

Advances in lipid-lowering therapy through gene-silencing technologies

Het effect is dosis-afhankelijk en reversibel (na staken trekt de pigmentatie binnen weken tot maanden weg)

doi: 10.1016/j.neuint.2012.12.014

MC1R (melanocortin 1 receptor) is a GPCR on melanocytes that controls melanin production