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We selected the joint pathway analysis module from the MetaboAnalyst platform ( which aims to represent whether the HPL-induced proteins and metabolites in a particular pathway are significantly enriched ( p values (unweighted) were chosen to evaluate the role of selected proteins or metabolites

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Supernatant was recovered following centrifugation at 16,000 g for 10 min at 4 C, and protein was quantified using the Pierce BCA protein assay kit (Thermo, Australia), according to manufacturers instructions

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