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Scott I, Webster BR, Chan CK, Okonkwo JU, Han K, Sack MN

Is it possible that a practical non-pharmaceutical-based treatment approach could be superior

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Through conducting hesperitin investigations, it was shown that mitochondrial apoptosis, neuroinflammatory, and transcription factors, which are controlled to reduce oxidative stress, are some of the triggering factors to induce neurodegeneration

We therefore propose that for a better understanding of ME/CFS, micro- and macro-circulatory failure, endothelial dysfunction, metabolic dysfunction, redox imbalance, inflammatory stimulation, and CNS inflammation need to be jointly considered (see Figure 2)