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In particular, in the last years, the importance of the development of a biomimetic scaffold, with structural and compositional features analogous to those of the native tissue, emerged as a key aspect

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Recent evidence suggests that cellular senescence plays a role in promoting fibrosis, especially in aged tissues, where stress-induced senescent myofibroblasts may exhibit delayed clearance with age

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Similarly, increases in intima-media thickness of the common carotid arteries, presence of coronary heart disease, and the presence of peripheral artery disease correlated with the Pro/Leu genotype compared to those homozygous for the Pro allele in a study of type 2 diabetic patients in Japan [91], consistent with a role for this polymorphism in cardiovascular risk