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Description

The combination of abdominal obesity, insulin resistance, high blood pressure, and dyslipidemia characterizes this syndrome

Subsequent to the receptor crosslinking, there is internalization of the AChR, which diminishes the number of receptors at the NMJ (54, 55)

Curr Obes Rep 14 , 68 (2025)

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Although phase III trials have shown that adverse effects are mild to moderate (eg, local irritation), the carcinogenic risk (eg, melanoma) and potential effects on the immune system (eg, T-cell suppression) under repeated light exposure need to be verified, and it is inconclusive whether resistance is related to autophagy pathway activation.68 Potential for Developing Novel Hypericin-Based Therapies Hypericin, a natural photosensitizer extracted from Hypericum perforatum , shows great promise in the treatment of skin diseases due to its photodynamic effect