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Studies have shown upregulation of HIF, VEGF, and VEGFR-2 in limb ischemia, especially in acute limb ischemia as opposed to chronic (102, 103)

Preclinical research has highlighted its potential across multiple biological systems, particularly in areas related to tissue repair, gastrointestinal protection, angiogenesis, and neural recovery
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Four papers in the Journal of Pharmacology and Experimental Therapeutics received formal expressions of concern

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