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doi: 10.1073/pnas.0503291102

Common causes of vitamin C deficiency include a diet poor in fresh fruits and vegetables, excessive alcohol consumption, smoking and certain diseases that increase the need for vitamin C

Thirdly, sub-inhibitory drug exposure can significantly upregulate the expression of ERG family, drug efflux pump genes, and stress tolerance genes in C

Xiao et al., 2016

ARA-290 has demonstrated significant efficacy in clinical trials for small fiber neuropathy and diabetic peripheral neuropathy, reducing pain scores and improving nerve fiber density