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Gerson proposed that coffee enemas helped stimulate the livers detoxification pathways, particularly for patients undergoing cancer treatment

Melanin modulation: The glutathione reroutes melanin production to pheomelanin (lighter pigment) instead of eumelanin

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Catalyzed by glutathione synthetase ( GSS ), this step is generally not rate-limiting under normal conditions but GSS variants that reduce enzyme activity can become limiting when step 1 is driving high -GluCys throughput, or when glycine availability is restricted

Alternatively, an enzyme-linked immunosorbent assay (ELISA) can be used to diagnose non-immediate sulfa allergy by measuring the amount of cytokines produced when using a sulfonamide antibiotics

doi: 10.3390/ijms18020325