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It also has been shown that in cisplatin-induced ototoxicity, resveratrol upregulates MicroRNA (miR) -455-5p to antagonize cisplatin ototoxicity by modulating the phosphatase and tensin homologue deleted on chromosome (PTEN)- Phosphatidylinositide 3-kinases (PI3K)- protein kinase B (AKT) axis, which reduces oxidative stress in hair cells, thereby protecting hearing and reducing hair cell damage (Liu et al., 2021b)

Empagliflozin in heart failure with a preserved ejection fraction

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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Zhang Z., Peng D., Zhu H., Wang X

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Several studies showed evident association between type II diabetes and cancer, in particular in liver and pancreas, organs persistently exposed to high levels of endogenous insulin 117,118,119