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Efficacy and Safety of Gut MicrobiotaBased Therapies in Autoimmune and Rheumatic Diseases: A Systematic Review and MetaAnalysis of 80 Randomized Controlled Trials. BMC Medicine 22, no

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Advanced glycation end products lead to oxidative stress and inflammation

Dashed lines represent 95 % confidence intervals

Pharmacologically, PPAR agonists represent an indirect route to elevate PGC-1-linked mitochondrial programs, as exemplified by bezafibrate, which activates PPAR signaling and increases PGC-1 expression to promote mitochondrial biogenesis in cellular models (Augustyniak et al., 2019)