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[DOI] [PubMed] [Google Scholar] 66.Khodamoradi K., Parmar M., Khosravizadeh Z., Kuchakulla M., Manoharan M., Arora H

Proteintech)

Pathogenesis of Parkinson's disease The pathogenesis of PD arises from a highly integrated network rather than being driven by a single linear pathway

Acetylation reduces SOD activity, resulting in higher mitochondrial O 2 levels, whereas irradiation, nutrient scarcity, and oxidative stress trigger SIRT3-mediated deacetylation of MnSOD to adequately enhance ROS scavenging within mitochondria to combat the emerging challenging conditions [16]

However, it can support a better quality of life in tandem with a healthy lifestyle

NAC (N-acetyl cysteine) is the most common way to boost glutathione levels, since oral glutathione has absorption challenges