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Metabolism of 2024 FDA approved small molecules part 1 By Julia Shanu-Wilson Involvement of active metabolites The number of small molecules approved by the FDA in 2024 totaled 31 out of 50 NMEs with 56% (28) of these comprising small molecule therapies
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The rationale was the dehydrogenation activity was only an unusual means to provide the trans -2-decenoyl-ACP for isomerization to the essential cis -3-decenoyl-ACP
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10.1111/asj.12739 Anim
