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This binding leads to the inhibition of the Keap1-dependent ubiquitination of Nrf2 TF, stabilizing it, to induce on time a battery of cytoprotective genes

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Over time, exposure to environmental pollutants, processed foods, alcohol, and medications can overwhelm the liver, leading to poor detoxification and increased oxidative stress[7]

Functions of TNF and its Receptors in Renal Disease: Distinct Roles in Inflammatory Tissue Injury and Immune Regulation
