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At the molecular level, the core clock transcriptiontranslation feedback loop is driven by the activators CLOCK and BMAL1, which induce the expression of the repressors PER and CRY1 (ref
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Magnetic resonance imaging for diagnosing lumbar spinal pathology in adult patients with low back pain or sciatica: a diagnostic systematic review

Elevated fibrinogen greatly increases the blood viscosity in the microcirculation by increasing red blood cell "stacking" or rouleaux formation