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This typically resolves on its own and can often be mitigated with proper hydration

Nature Reviews Neuroscience

The results of the present study clearly point out that increasing corticosterone levels indicate that aspartame acts as a chemical stressor and that aspartame metabolite could accelerate lipid peroxidation leading to an increase in oxidative stress and altered cytokine secretion

21 The study confirms which demonstrate the utility of an in vivo electrochemical method to follow modifications in the NO oxidation current within the spinal dorsal horn in situations related to nociception

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Therapeutic targeting of the redox balance is regarded as an effective strategy for treating oxidative stressrelated diseases, such as supplementation of direct antioxidants and enhancement of endogenous antioxidant defense network