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Evidence for loading protocols remains anecdotal, and many users achieve good results with consistent moderate dosing from day one

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E2 appears to exert anorexigenic effects, whereas P4 in the presence of E2 tends to increase appetite and preference for energy-dense foods, an effect further modulated by changes in leptin, ghrelin, peptide YY (PYY), and possibly central insulin signaling [114]

Duggal, N

In this sense, AMK is a better OH - and NO eliminator than melatonin and AFMK [89]

(2024) 22(10):202332.e6