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Principal component analysis confirmed that the drug combination caused the greatest aminoacidic (Supplementary Fig

Figure 1B shows high pyocyanin producing CF isolates AES-1R, AES-2, LESB58, LES431 produced significantly ( P 0.05)

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Certainly, several extrarenal hypotheses have been proposed over the years to better understand some observed metabolic effects of loop diuretics, mostly bumetanide and furosemide, in humans and animal models