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Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoem-bryonic antigen single-chain Fv-Fc antibody fragments

This observation was mechanistically determined to be in part due to A 142 binding directly to COX1 and inducing loss of enzymatic activity of the greater mitochondrial electron transport chain complex 4 (C4), of which COX1 is an integral part

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This per-tim complex accumulates in the cytoplasm before entering the nucleus to inhibit its own transcription by repressing the transcriptional activators Clock (Clk) and cycle (cyc) (Lee et al., 1999

Surprisingly, the results of this study showed that alamandine alone increased urine volume