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Nat Rev Neurosci 15(1):4353 Yamada ES, Respondek G, Mssner S, De Andrade A, Hllerhage M, Depienne C et al (2014) Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice

PMID 35301358

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A 2011 systematic review of clinical data suggested that citicoline could hasten the resorption of cerebral edema and improve the recovery of consciousness and neurologic disorders in severe TBI cases (classified by Glasgow Coma Scale [GCS] scores of 8) (5)