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Third, variability in study design further complicates interpretation

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MTHFR C677T impairs methylfolate production and causes homocysteine to accumulate

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Across seventeen representative studies, formulations incorporating polyphenols, terpenoids, polyamines, polysaccharides, fatty acids, bioactive peptides, amino acids, vitamins, and minerals produced measurable improvements of approximately 1540% in biomarkers and functional indices associated with ageing (Table 9) [168,169,170]

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