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10.3389/fonc.2024.1345129 24 BudiH

doi: 10.1038/s41419-017-0135-z

Barrier-protected packaging is critical for peptide stability

B12 reduces pro-inflammatory cytokines and oxidative stress in nerve cells (Yang et al., 2021)

In addition, a recent study in hepatocellular carcinoma identified HIF-1 as a regulator of PINK1 and mitophagy by promoting STOML2-mediated mitochondrial PINK1 stabilization [66], but it is not known whether this mechanism is present in other tissues

The authors express concern that there is not yet clear guidance on supplementation route and methods, and they discuss studies exploring this
