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In the United States, 20%40% of individuals with diabetes develop DN, which is the leading cause of ESRD (Reutens and Atkins, 2011)
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Mitochondria utilize about 90% of the bodys oxygen for ATP production through oxidative phosphorylation, leading to ROS generation as a byproduct [51,52]

Fiber cells close to the surface of the lens have a lower protein concentration than fiber cells deeper in the lens, creating a gradient of refractive index that at least partially corrects for spherical aberration

172 Contrary to the other substrates that undergo a hydrogen abstraction on the 8 position, the hydrogen abstraction occurs on the 5 position of ALA, creating 12-HOTrE as the main product (Scheme 10)

Therefore, they can consider freezing sperm before treatment to ensure their fertility
