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This is supported by the observations that: (1) inorganic Hg accumulation in the proximal tubule region of the nephron is mainly handled by filtrationreabsorption as glutathione-Hg conjugates 5,6 , and (2) the renal uptake of glutathione-Hg conjugates occurs mainly at the luminal membrane via a molecular mimicry mechanism using animo acid transporters 9,12

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One of glutathione's key biological roles is aiding liver detoxification

Cell 119 : 679691 Metherell LA et al

The keywords included dry eye, mitochondrial dysfunction, reactive oxygen species (ROS), mitochondrial apoptosis, mitochondrial DNA (mtDNA), and therapy. We included articles published in peer-reviewed journals that focused on mitochondrial dysfunction in DE, discussed therapeutic strategies targeting this dysfunction, and involved human subjects, animal models, or in vitro studies relevant to the pathophysiology and treatment of DE

doi: 10.3181/00379727-176-41867