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The gut communicates with the liver via the gutliver axis through the biliary system and the portal vein, transferring gut-derived components or the gut microbes themselves to the liver and initiating the immune response

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The condition is accompanied by a decrease in the amount of protein in muscle tissue

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and (3) patients with overt hypothyroidism or autoimmune thyroiditis (e.g., Hashimotos disease), for whom a KD may be either beneficial or destabilizing depending on diet quality, energy balance, and adherence to repletion protocols

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