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Dietary methionine supplementation improves cognitive dysfunction associated with Transsulfuration pathway upregulation in subacute aging mice

This ratio of GSH: GSSG is maintained by the action of GSSG reductase, which requires NADPH+ as the reducing cofactor

RNS and RSS both contribute to fluctuations in redox homeostasis within the cells and, like ROS, are mainly produced within mitochondria [42,43,44,45]

Such dysregulation has been linked to myriad pathologies, underscoring the clinical significance of maintaining ER redox homeostasis

Gipp et al., 1995

In plants, under sulfur-limiting conditions they optimize nitrogen assimilation to maintain metabolic homeostasis