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Free radicals, glycation, and apoptosis are common factors that contribute to the aging of normal cells and RBCs, while the blood is a very complex mixture of many different components, plasma, RBCs, WBCs, and platelets, electrolytes, hormones, and waste products, which made the aging and clearance process of RBCs more complex, what's more, natural antibodies, immunoglobulin G, opsonin, and the complement system, have all been proven to contribute to this process 6

10.1016/j.mito.2009.11.003 [DOI] [PMC free article] [PubMed] [Google Scholar] Doonan R., McElwee J.J., Matthijssens F., Walker G.A., Houthoofd K., Back P., Matscheski A., Vanfleteren J.R., and Gems D

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