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Instead of opening with why AOD-9604 should work, it opens with why it often does not work in the way people assume, then builds forward from primary literature to a more accurate model of who it actually benefits and under what conditions

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demonstrated in a macrophage-specific IGF-1 Apoe -/- mouse model that macrophage-derived IGF-1 inhibited the expression of chemokine (C-X-C motif) ligand 12 (CXCL12), reduced monocyte recruitment to plaques, and favoured macrophage cholesterol efflux (60)