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26 Mitochondria are double membrane- bound organelles that generate the cells energy through the production of adenosine triphosphate (ATP)

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however, excess MAO-B activity increases with age and depletes dopamine levels through excessive dopamine metabolism

The RE (commonly Ag/AgCl) maintains a highly stable potential, providing a constant reference against which the WE potential is controlled

Numerous preclinical studies with pharmacological Nrf2 activators (e.g., sulforaphane, naringenin, curcumin) have demonstrated significant cardioprotection in MIRI models, attenuating injury, reducing infarct size, and decreasing oxidative stress, inflammation, and cell death (Wang R