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To confirm that weight loss in the setting of cysteine deficiency is due to the concurrent induction of the ISR and OSR, we fed mice a no-Trp diet while administering l-buthionine sulfoximine (BSO), a specific inhibitor of -glutamyl cysteine synthase, which decreases GSH but not cysteine (Fig

from the National Institute on Aging and the Muscular Dystrophy Association, and by a grant to N.R

Zhang, X.-Y., Cao, J.-B., Zhang, L.-M., Li, Y.-F

[DOI] [PubMed] [Google Scholar] 123.Jackson AC, Liu J, Vallanat B, Jones C, Nelms MD, Patlewicz G, et al

Biological tools have a greater affinity in screening the hits with various approaches and identifications of multiple targets 13,14