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Learning Objectives Examine the roles of chelation and luspatercept in managing iron overload in acquired sideroblastic anemias and MDS Evaluate the indication for iron chelation therapy and luspatercept treatment in patients with MDS-RS Understand the pathomechanism of systemic and mitochondrial iron overload in MDS with ring sideroblasts CLINICAL CASE A 69-year-old man, previously in good health, presents with anemia (hemoglobin 9.1 g/dL) and dyspnea on exertion

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