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Br J Pharmacol2020 Jun;177(12):2848-2859

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BRD4 Proteolysis Targeting Chimera (PROTAC) Leads to Sustained Degradation of BRD4 with Broad Activity Against Acute Leukemias and Overcomes Stroma Mediated Resistance by Modulating Surface Expression of CXCR4

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The AOD9604 results were most pronounced in subjects with higher baseline body fat percentages, suggesting greater efficacy in those with more fat to lose

Patient populations show distinct preferences based on medical needs and risk factors
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