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Briefly, based on the activity coefficients magnitudes it follows that the solvent-solvent interactions are higher in neat water (with Hildebrand solubility parameter = 47.8 MPa) and they are smaller in ethanol (with = 26.5 MPa) (50)

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The BBB restricts effective drug delivery, but nanoparticle-based systems provide a promising solution by improving stability, targeting, and brain accumulation while reducing toxicity

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Permeability Characteristics of a New Antifungal Topical Amphotericin B Formulation with -Cyclodextrins

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