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A phase III, multinational, randomized parallel-group study (TENERE) was designed as a superiority trial to compare the effectiveness, defined as time to failure (first occurrence of confirmed relapse or permanent treatment discontinuation for any reason, whichever came first), and tolerability of oral teriflunomide 7 mg daily (n=109) or oral teriflunomide 14 mg daily (n=111) versus subcutaneous interferon beta-1a 44 mcg, three times weekly (n=104) (105)

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Always check the BUD on your specific vial and do not use it beyond that date
Sometimes it is most definitely necessary to have a cortisone injection to achieve significant pain relief

If a claim implies systemic benefits, treat it as a higher-uncertainty category and prioritise evidence quality over confidence
Scars left from acne can be a great cause of concern to affected patients, especially if they occur on the face