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The current studys light microscopic analysis revealed a significant atrophic and degenerative alteration in the corpora lutea and ovarian follicles in all stages, because DOX-intoxicated animals had a considerably larger mean proportion of atretic follicles and deteriorated corpora lutea than the untreated group

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A 2017 study published in the Journal of Molecular Medicine by Hsieh et al

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Additionally, a considerable proportion of patients with depression respond inadequately to traditional antidepressant treatment and are classified as having treatment-resistant depression (Sforzini et al., 2022)