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These memory lymphocytes can then be activated within these organs, producing inflammation and tissue damage

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The effect of exercise training on resting concentrations of peripheral Brain-Derived Neurotrophic Factor (BDNF): a meta-analysis

Cell Rep 10(8):12691279

The progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta leads directly to dopamine deficiency, underpinning the hallmark motor symptoms such as bradykinesia, resting tremor, and rigidity, as well as contributing to nonmotor symptoms including autonomic, mood, and cognitive disorders [2]

These differentially expressed proteins were involved in several important biological processes as follows: 95.4% were associated with metabolic process, 47.2% with the oxidation-reduction process, and 30.6% with the electron export (Table 1)