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They work by targeting the GIP and GLP-1 receptors in the brain's appetite control centers, including the hypothalamus [17, 18]

Supporting a dominant role for diet composition in establishing the Firmicutes : Bacteroidetes ratio, previous work has shown that mice maintained on a high-fat diet had a similar cecal Firmicutes : Bacteroidetes ratio to those maintained on a high-carbohydrate diet 77